Pola Chemical Industries: Patent for Producing Human Hair Follicle Organoids
In March 2025, a Japan-based company called Pola Chemical Industries was granted a Japanese patent for producing human hair follicle organoids. It was first filed in 2023. Pola Chemical is part of the much larger Pola Orbis Holdings Group, which focuses on developing new skincare and cosmetic products.
The new patent pertains to a novel technique for producing human hair follicle organoids. It comprises co-culturing epithelial cells, mesenchymal cells and pluripotent stem cells in specific ratios relative to each other.
Note that a number of other companies and researchers have been working on creating pigmented hair follicle organoids with hair bulbs and hair shafts. These include the highly reputable Dr. Junji Fukuda from Japan; and newer lesser known newere entities from South Korea such as Kangstem Biotech and AttisLab.
According to “Theo”, this novel method can produce human hair follicle organoids (including the hair shaft and hair bulb) using only human adult stem cells. In contrast, Dr. Junji Fukuda’s original method used mixed stem cells from humans and mice. Pola Chemical’s technology can also be applied to create human hair follicle primordium, like the Dr. Takashi Tsuji method. It can be used for hair transplantation and hair follicle regeneration.