Recently, I read about an interesting Japanese clinic named Aoyama Renacel that is offering a unique stem cell based hair growth treatment. It combines autologous stem cells derived from baby teeth with adipose-derived stem cells (ADSC). I have covered the latter numerous times on this blog, but never the former.
Stem Cells Derived from Teeth for Hair Growth
In 2025, the Japanese government accepted Aoyama Renacel’s Type II regenerative medicine provision plan to use its technology for the treatment of thinning hair and androgenetic alopecia in both men and women. The submission was titled “Treatment of alopecia using autologous adipose-derived mesenchymal stem cells.”
The hair loss treatment entails simultaneously injecting into the scalp two separate types of cells:
- Culture supernatant of stem cells derived from deciduous tooth pulp.
- Adipose-derived stem cells.
The tooth pulp derived stem cells contain 10-20 times more major growth factors, including vascular endothelial growth factor (VEGF). I have discussed the link between VEGF and hair growth several in the past, including in my post on growth factors in PRP. Also of note, hair growth drug Minoxidil upregulates the expression of VEGF in human hair DP cells. Per a quote on Renacel’s website:
“Measurements by a reliable external testing agency have proven that this supernatant contains several dozen times more major growth factors, including VEGF (vascular endothelial growth factor), which is essential for hair regeneration, than general culture supernatants.”
Further details about the stem cell culture supernatant also mention cytokines and exosomes. They also have a table that compares various stem cell culture supernatants based on what part of the human they are derived from:
- Deciduous tooth pulp.
- Umbilical cord.
- Fat.
- Bone marrow.
The below video explains this new tooth pulp stem cell technology for androgenetic alopecia in detail.
Japan and Teeth
It looks like in addition to curing hair loss, Japan also has the best chance at curing tooth loss.